Clinical Performance and Tolerability of LimpiAD Topical Foam in Dogs with Canine Atopic Dermatitis: A Prospective Multicentre Real-Word Study
Abstract
This prospective, real-world multicentre study evaluated the clinical performance of LimpiAD 2.5% Plus topical foam in 52 dogs affected by canine atopic dermatitis (CAD), used either as monotherapy or in combination with systemic therapy.
By week 6, corresponding to the primary endpoint assessment, the response rates increased 63.5% of all enrolled dogs achieved a ≥50% reduction in CADESI-04 -50. In the LimpiAD monotherapy group, 57.1% of dogs reached CADESI-04-50, while the LimpiAD + systemic therapy group showed the highest response rate, with 70.8% of dogs meeting the endpoint.
A parallel and significant reduction in pruritus was observed, as shown by decreasing owner-reported PVAS scores throughout the study. Improvement was faster when LimpiAD was combined with systemic therapy, while monotherapy showed a slower but sustained response.
LimpiAD was well tolerated, with no serious adverse events reported and high owner acceptability and adherence.
Overall, the findings support LimpiAD as a safe and effective barrier-supportive topical treatment for CAD, providing clinically relevant improvements in both lesion severity and pruritus, particularly when used as part of combination therapy.
These data are derived from an unpublished study and were partially presented as a poster at the SIDEV scientific congress held on 10–12 October 2025.
Scientific Report: In vitro study of HAc40 and c40 influence on Staphylococcus pseudintermedius and Staphylococcus aureus colonization to canine keratin: evaluation of barrier properties
Abstract
Staphylococcus pseudintermedius, the primary pathobiont in canine dermatitis and pyoderma, exhibits a strong capacity to adhere to keratinized surfaces and keratinocytes, a critical step in colonization and infection.
This study evaluated the effect of HAc40 using an in vitro canine keratin model that mimics the keratinized layer of skin and fur. HAc40 significantly reduced the colonization of two S. pseudintermedius strains, particularly when applied as a pre-treatment, highlighting its impact on the early phases of bacterial seeding.
Overall, HAc40 appears to act by forming a protective barrier over keratinized surfaces rather than through a direct anti-adhesive mechanism, thereby limiting bacterial colonization. These findings support its potential role in controlling the initial stages of pathogen establishment in canine skin.